Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia
نویسندگان
چکیده
منابع مشابه
The role of left and right Locus Coeruleus in formalin test in rats
Introduction: Pain as a complex process in the CNS has been extensively studied by many researchers. It has been found that pain is controlled by certain pathways in the CNS, one of most important of which is the descending noradrenergic system. The pathway begins with Locus Coeruleus (LC) nucleus and ends in the spinal cord. In this study, formalin test was used as a chemical and tonic pain...
متن کاملNeuroinflammation, AD, and Dementia
1Department of Oncology and Neurosciences, ‘G. D’Annunzio’ University of Chieti-Pescara, Italy 2Department of Neurology, Hadassah Hebrew University Medical Center, P.O. Box 12000, Jerusalem 91120, Israel 3 Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224-6825, USA 4Centro de Envejecimiento y Regeneración, Centro de Regulación Celular y Patoloǵıa “Joaquı́n V. Luco,” I...
متن کاملStriatal Neuroinflammation Promotes Parkinsonism in Rats
BACKGROUND Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disorder with unknown cause, but it has been suggested that neuroinflammation may play a role in pathogenesis of the disease. Neuroinflammatory component in process of PD neurodegeneration was proposed by postmortem, epidemiological and animal model studies. However, it remains unclear how neuroinflammatory factors ...
متن کاملTitle: Striatal Neuroinflammation Promotes Parkinsonism in Rats
The specific role of neuroinflammation in the pathogenesis of Parkinson's disease remains to be fully elucidated. By infusing lipopolysaccharide (LPS) into the striatum, we investigated the effect of neuroinflammation on the dopamine nigrostriatal pathway. Here, we report that LPS-induced neuroinflammation in the striatum causes progressive degeneration of the dopamine nigrostriatal system, whi...
متن کاملNeuroinflammation in Lewy body dementia.
Neuroinflammation is increasingly recognized as a key factor in the pathogenesis of neurodegenerative conditions. However, it remains unclear whether it has a protective or damaging role. Studies of Alzheimer's disease and Parkinson's disease have provided much of the evidence for inflammatory pathology in neurodegeneration. Here we review the evidence for inflammation in dementia with Lewy bod...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21228630